化学品概述
还原型为分散的针状结晶,氧化型系花瓣状结晶,二者均易溶于水及酸性溶液,前者水溶液呈桃红色,后者呈深红色。对热都较稳定。而前者较后者更稳定些,分子量约11000-13000。。
基本信息
- 中文名称:
- 中文别名:
- 英文名称:
- 英文别名:
- 分子式:
- 分子量:
- CAS:
- EINECS编号:
- MDL编号:
- 精确质量:
- InChI:
- InChI Key:
- MOL文件:
- PSA:
- LogP:
- FEMA编码:
- COE编码:
理化性质
-
外观性质:
powder;
-
熔点:
300 °C
- 沸点:
- 密度:
- 折射率:
- 比旋光度:
- 闪点:
- 溶解性:
-
酸度系数(pKa):
100 g/L (20 ºC)
- 相对极性:
- PH值:
- 爆炸极限值(explosive limit):
- 敏感性:
-
储存条件:
−20°C
- 检测方法:
- 蒸气压:
-
Merck:
13,2820
- BRN:
- NIST化学物质信息:
-
EPA化学物质信息:
http://iaspub.epa.gov/sor_internet/registry/substreg/searchandretrieve/advancedsearch/search.do?search=?search=&searchCriteria(advancedCriteria)=casNumber=9007-43-6
安全信息
-
危化品标志:
Xi,B,Xn
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危化代码:
36/37/38-20/21/22
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安全代码:
26-36-37/39-24/25
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海关编码/HS编码:
35040000
- 危化品运输编码:
-
WGK Germany:
3
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RTECS:
HA5365000
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TSCA:
Yes
- 危化等级:
- 包装类别:
- 毒理资料:
- 灭火剂:
应用领域
细胞呼吸激活药。对组织中细胞的氧化、还原过程具有迅速的酶促作用。用于急救或辅助治疗中因各种原因引起的组织缺氧。对抗癌药物引起的白血球降低,四肢循环障碍,肝疾患,肾炎亦有一定的治疗作用。来自三羧酸循环产生的琥珀酸辅酶A,其肽链仅有104个氨基酸,体内大量存在,无需外源补充;细胞色素C是生物氧化的非常重要的电子传递体,在线粒体崤上与其它氧化酶排列成呼吸链,参与细胞呼吸过程。肝细胞炎症时细胞膜通透性较高,细胞色素C可进人细胞内。可治疗肝衰竭,增加细胞氧化,提高氧利用。是含铁的结合蛋白,有抗原。用作细胞呼吸激活药
制备方法/合成路线
方法一:以心肌为原料。方法二:以酵母为原料。
参考资料
- Electron transport protein found in the mitochondrial intermembrane space of all eukaryotes. Transfers electrons between complex III and complex IV of the respiratory chain. Synthesized in the cytosol as apocytochrome c, then transported across the mitochondrial outer membrane. Heme lyase covalently attaches the heme c prosthetic group, a derivative of iron protoporphyrin IX, q.v. During apoptosis, cytochrome c is released from the mitochondia and acts as a cofactor for caspase, q.v. activation. Human form consists of a single polypeptide chain of 104 amino acid residues with the heme group covalently attached through thioether linkages at cysteine residues 14 and 17. Isoln from muscle tissue: C. A. MacMunn, Proc. R. Soc. London 39, 248 (1886). Identification and absorption spectra of cellular pigments called cytochromes: D. Keilin, Proc. R. Soc. London Ser. B 98, 312 (1925). Redox function and isoln from baker's yeast: idem, ibid. 106, 418 (1930). Absorption spectrum: M. Dixon et al., ibid. 109, 29 (1931). Improved prepn from vertebrate and invertebrate sources: E. Margoliash, O. F. Walasek, Methods Enzymol. 10, 339 (1967). Isoln and purification from plant sources: M. Richardson et al., Phytochemistry 9, 2271 (1970). Oxidation-reduction potentials: F. L. Rodkey, E. G. Ball, J. Biol. Chem. 182, 17 (1950). First crystn from King penguin: G. Bodo, Nature 176, 829 (1955). Electron transport function in respiration: E. C. Slater, Adv. Enzymol. Relat. Subj. Biochem. 20, 147 (1958). First elucidation of amino acid sequence was horse heart: E. Margoliash et al., J. Biol. Chem. 237, 2148, 2151, 2161 (1962); of human heart: H. Matsubara, E. L. Smith, ibid. 238, 2732 (1963). Crystal structure of horse heart and bonito cytochrome c: R. E. Dickerson et al., J. Biol. Chem. 246, 1511 (1971). Structural properties of apo-, iron-free porphyrin, and native cytochrome c: W. R. Fisher et al., J. Biol. Chem. 248, 3188 (1973). Discovery and characterizat
MSDS
![](http://s.ewormhole.ostc.com.cn/res/images/list_page/y_hxp07.png)
图谱
计算化学数据
-
疏水参数计算参考值(XlogP):
-1.1
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氢键供体数量 :
6
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氢键受体数量:
9
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可旋转化学键数量:
9
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拓扑分子机型表面积(TPSA) :
209
-
重原子数量:
32
-
形式电荷:
0
-
复杂度:
767
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同位素原子数量:
0
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确定原子立构中心数量:
1
-
不确定原子立构中心数量:
0
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确定化学键立构中心数量:
0
-
不确定化学键立构中心数量:
0
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共价键单元数量:
1