化学品概述
基本信息
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中文名称:
蜕皮激素
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中文别名:
蜕皮甾酮;Α-蜕化激素;Α-蜕皮甾酮(2Β,3Β,5Β,22R)-2,3,14,22,25-五羟基胆甾醇-7烯-6酮;(2Β,3Β,5Β,22R)-2,3,4,20,22,25-六羟基胆甾醇-7-烯-6-酮;20-羟基蜕化素;Β-蜕化激素;Β-蜕皮甾酮;蜕皮松
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英文名称:
Ecdysone
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英文别名:
2,3,14,22,25-pentahydroxy-,(2-beta,3-beta,5-beta,22r)-cholest-7-en-6-on;2-beta,3-beta,14,22,25-pentahydroxy-,(20s,22r)-5-beta-cholest-7-en-6-on;ECDYSONE;ECDYSONE, ALPHA-;2BETA,3BETA,14ALPHA,22[R],25-PENTAHYDROXY-7-CHOLESTEN-6-ONE;ALPHA-ECDYSON;ALPHA-ECDYSONE;ALPHA-ECDYSTERONE
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分子式:
C27H44O6
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分子量:
464.63466 [g/mol]
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CAS:
3604-87-3
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EINECS编号:
222-760-4
- MDL编号:
-
精确质量:
464.313789
- InChI:
- InChI Key:
-
MOL文件:
/Mol/3604-87-3.mol
- PSA:
- LogP:
- FEMA编码:
- COE编码:
理化性质
- 外观性质:
-
熔点:
242°C
- 沸点:
- 密度:
- 折射率:
-
比旋光度:
20578 +62°
- 闪点:
- 溶解性:
- 酸度系数(pKa):
- 相对极性:
- PH值:
- 爆炸极限值(explosive limit):
- 敏感性:
-
储存条件:
2-8°C
- 检测方法:
- 蒸气压:
-
Merck:
13,3525
- BRN:
- NIST化学物质信息:
- EPA化学物质信息:
安全信息
- 危化品标志:
- 危化代码:
-
安全代码:
22-24/25
- 海关编码/HS编码:
- 危化品运输编码:
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WGK Germany:
3
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RTECS:
FZ8170000
- TSCA:
- 危化等级:
- 包装类别:
- 毒理资料:
- 灭火剂:
应用领域
可促进细胞生长,刺激真皮细胞分裂,对人体也有促进蛋白质合成作用
制备方法/合成路线
参考资料
- Polyhydroxylated steroids formerly known as ecdysones. Originally identified as insect molting hormones controlling the pupation of insects. Later shown to be involved in many complex developmental processes in metamorphosis, differentiation and reproduction. Ecdysteroids have been detected in invertebrate species of several phylla belonging to the Protostomia and in some plant species. The terms zooecdysteroids and phytoecdysteroids are used to distinguish ecdysteroids isolated from animal species from those of plant origin. Nomenclature: T. W. Goodwin et al., Nature 272, 122 (1978). The two major ecdysteroids isolated are ecdysone and 20-hydroxyecdysone. Configuration: M. Koreeda et al., J. Am. Chem. Soc. 93, 4084 (1971). Chromosomal action: M. Ashburner, Nature 285, 435 (1980). GC and HPLC determn: R. P. Evershed et al., J. Chromatogr. 390, 357 (1987). Reviews: Kilby, Discovery 18, 13 (1957); P. Karlson, Angew. Chem. Int. Ed. 2, 175-182 (1963); K. Nakanishi, Pure Appl. Chem. 25, 167-195 (1971); M. Koreeda, B. A. Teicher, Anal. Biochem. Insects 1977, 207-240; P. Karlson, Dev. Endocrinol. 7, 1-11 (1980). Book: Ecdysone: From Chemistry to Mode of Action, J. Koolman, Ed. (Thieme, New York, 1989) 482 pp.
- MSDS
图谱
计算化学数据
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疏水参数计算参考值(XlogP):
1.7
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氢键供体数量 :
5
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氢键受体数量:
6
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可旋转化学键数量:
5
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拓扑分子机型表面积(TPSA) :
118
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重原子数量:
33
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形式电荷:
0
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复杂度:
821
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同位素原子数量:
0
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确定原子立构中心数量:
10
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不确定原子立构中心数量:
0
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确定化学键立构中心数量:
0
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不确定化学键立构中心数量:
0
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共价键单元数量:
1