化学品概述
基本信息
-
中文名称:
亚精胺
-
中文别名:
亚精胺盐酸盐;精脒;N-(3-氨基丙基);N-(3-氨基丙基)-1,4-丁二胺;亚精胺;亚精胺 精咪;精三胺;亚精胺,99%
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英文名称:
Spermidine
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英文别名:
1,8-DIAMINO-4-AZAOCTANE;SPERMIDINE FREE BASE;SPERMIDINE;OMEGA-AMINOBUTYL-OMEGA-AMINOPROPYLAMINE;N1-(3-AMINOPROPYL)BUTANE-1,4-DIAMINE;N-(3-AMINOPROPYL)-1,4-BUTANDIAMINE;N-[3-AMINOPROPYL]-1,4-BUTANEDIAMINE;N-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE
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分子式:
C7H19N3
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分子量:
145.24586 [g/mol]
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CAS:
124-20-9
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EINECS编号:
204-689-0
- MDL编号:
-
精确质量:
145.157898
- InChI:
- InChI Key:
-
MOL文件:
124-20-9.mol
- PSA:
- LogP:
- FEMA编码:
- COE编码:
理化性质
-
外观性质:
Liquid After Melting;Clear colorless
-
熔点:
23-25 °C
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沸点:
128-130 °C (14 mmHg)
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密度:
1.00 g/mL at 20 °C
-
折射率:
n20/D 1.479(lit.)
- 比旋光度:
-
闪点:
>230 °F
-
溶解性:
>230 °F
-
酸度系数(pKa):
Miscible with water, ethanol and ether.
- 相对极性:
-
PH值:
12.0-13.5 (25℃, 1M in H2O)
- 爆炸极限值(explosive limit):
-
敏感性:
Air Sensitive
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储存条件:
2-8°C
- 检测方法:
- 蒸气压:
-
Merck:
14,8742
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BRN:
1698591
- NIST化学物质信息:
-
EPA化学物质信息:
http://iaspub.epa.gov/sor_internet/registry/substreg/searchandretrieve/advancedsearch/search.do?search=?search=&searchCriteria(advancedCriteria)=casNumber=124-20-9
安全信息
-
危化品标志:
C
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危化代码:
34
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安全代码:
26-36/37/39-45-27
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海关编码/HS编码:
29212900
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危化品运输编码:
UN 2735 8/PG 2
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WGK Germany:
3
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RTECS:
EJ7000000
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TSCA:
Yes
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危化等级:
8
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包装类别:
III
- 毒理资料:
- 灭火剂:
应用领域
抑制神经元NO合成酶(nNOS)。结合并沉淀DNA; 也用于纯化DNA结合蛋白。刺激T4 聚核苷酸激酶活性。
制备方法/合成路线
参考资料
- Biogenic polyamine formed from putrescine; a precursor of spermine, q.q.v. First detected in human sperm, but occurs widely in nature. Essential for both normal and neoplastic tissue growth. Synthesis: H. W. Dudley et al., Biochem. J. 20, 1082 (1926); 21, 97 (1927); J. V. Braun, W. Pinkernelle, Ber. 70, 1234 (1937); M. Danzig, H. P. Schultz, J. Am. Chem. Soc. 74, 1836 (1952). For reviews of the early literature, see M. Guggenheim, Die biogenen Amine (S. Karger, Basel, 4th ed., 1951) 619 pp; H. Tabor et al., Annu. Rev. Biochem. 30, 579-604 (1961). Role in cell growth processes: C. W. Tabor, H. Tabor, ibid. 45, 285 (1976); J. Janne et al., Biochim. Biophys. Acta 473, 241 (1978); C. W. Porter, R. J. Bergeron, Science 219, 1083 (1983). Formation and interconversion of spermidine and putrescine in mammalian cells: A. E. Pegg et al., Adv. Enzyme Regul. 19, 427 (1980). Effect on polypeptide chain elongation in vitro: A. K. Abraham, A. Pihl, Eur. J. Biochem. 106, 257 (1980). Regulation of tRNA methyltransferase activity: M. Mach et al., Biochem. J. 202, 153 (1982). HPLC study: C. E. Prussak, D. H. Russell, J. Chromatogr. 229, 47 (1982). Interaction with actin, q.v.: C. Oriol-Audit, Biochem. Biophys. Res. Commun. 105, 1096 (1982). Studies on use as a biochemical tool in cancer research: A. Thyss et al., Eur. J. Cancer Clin. Oncol. 18, 611 (1982); V. Quemener et al., J. Nat. Prod. 45, 608 (1982); C. W. Porter et al., Cancer Res. 42, 4072 (1982). Toxicity study: P. R. Langford et al., J. Antibiot. 35, 1387 (1982). Reviews: T. C. Theoharides, Life Sci. 27, 703-713 (1980); O. Heby, Differentiation 19, 1-20 (1981); L. Stevens, Med. Biol. 59, 308-313 (1981). Book: Polyamines in Biology and Medicine, D. R. Morris, L. J. Marton, Eds. (Dekker, New York, 1981) 512 pp.
- MSDS
图谱
计算化学数据
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疏水参数计算参考值(XlogP):
-1
-
氢键供体数量 :
3
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氢键受体数量:
3
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可旋转化学键数量:
7
-
拓扑分子机型表面积(TPSA) :
64.1
-
重原子数量:
10
-
形式电荷:
0
-
复杂度:
56.8
-
同位素原子数量:
0
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确定原子立构中心数量:
0
-
不确定原子立构中心数量:
0
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确定化学键立构中心数量:
0
-
不确定化学键立构中心数量:
0
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共价键单元数量:
1