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中国科学院呼吸道疾病国家重点实验室张天宇导师课题组

论文

Islam M, Hameed A, Mugweru J,... , Drug Resistance Mechanisms and Novel Drug Targets for Tuberculosis Therapy., J Genet Genomics. , 2017 , 44 ,21-37

Guo J, Wang C, Han Y,... , Identification of Lysine Acetylation in Mycobacterium abscessus Using LC-MS/MS after Immunoprecipitation, J Proteome Res , 2016 , 15 , 8 ,2567-2578

Tan S*, Rao Y, Guo J,... , The Influence of Pyrazinamide Monoresistance on Treatment Outcomes in Tuberculosis Patients from Southern China, J Tuberculosis Res , 2016 , 4 ,9-17

Makafe G, Cao Y, Tan Y,... , Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis., Antimicrob Agents Chemother. , 2016 , 60 , 5 ,3202-3206

Njire M, Tan Y, Mugweru J,... , Pyrazinamide resistance in Mycobacterium tuberculosis: review and update., Adv Med Sci. , 2016 , 61 , 1 ,63-71

刘洋,王邦兴,刘志永,韩轶,谭耀驹,李昕洁,刘健雄,谭守勇*,张天宇*。 , 非一线抗结核药物耐药机制及耐药性诊断研究进展。, 遗传 , 2016 , 38 , 10 ,928-939

张天宇,谢建平,王明贵。 , 抗生物耐药性研究领域的机遇和挑战。, 遗传 , 2016 , 38 , 10 ,857-858

Tang J, Wang B, Wu T,... , Design, synthesis and biological evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as novel anti-tubercular agents., ACS Med Chem Lett. , 2015 , 6 ,814-818

Liu T, Wang B, Guo J,... , Role of folp1 and folp2 genes in the action of sulfamethoxazole and trimethoprim against mycobacteria, J Microbiol Biotechnol , 2015 , 25 , 9 ,1559-1567

Yang F, Njire M, Liu J,... , Engineering more stable, selectable marker-free autoluminescent mycobacteria by one step. , PLoS One , 2015 , 10 , 1

Yang F, Tan YJ, Liu J,... , Efficient construction of unmarked recombinant mycobacteria using an improved system., J Microbiol Methods. , 2014 , 103 ,29-36

Tan YJ, Hu ZQ, Zhang T*,... , Role of pncA and rpsA gene sequencing in detection of pyrazinamide resistance in Mycobacterium tuberculosis isolates from southern China., J Clin Microbiol. , 2014 , 52 , 1 ,291-297

Tan S*, Sun D, Zhang T,... , Risk factors for hemoptysis in pulmonary tuberculosis patients from southern China: a retrospective study., J Tuberculosis Res. , 2014 , 2 ,173-180

Zhang T, Li SY, Converse PJ,... , Rapid, serial, non-invasive assessment of drug efficacy in mice with autoluminescent Mycobacterium ulcerans infection. , PLoS Negl Trop Dis. , 2013 , 7 , 12 ,e2598

Chen C, Lu M, Liu Z,... , Synthesis and evaluation of 2-amino-4h-pyran-3-carbonitrile derivatives as antitubercular agents. , Open J Med Chemi. , 2013 , 3 ,128-135

梁镇兴,张可,谭耀驹,... , 利用自主发光结核分枝杆菌快速连续检测抗结核药物的细胞内活性。, 实用医学杂志 , 2013 , 29 , 23 ,209-212

Zhang T, Li SY, Nuermberger EL*. , Autoluminescent Mycobacterium tuberculosis for rapid, real-time, non-invasive assessment of drug and vaccine efficacy. , PLoS One , 2012 , 7 ,e29774.

Zhang T, Li SY, Williams KN,... , Short-course chemotherapy with TMC207 and rifapentine in a murine model of latent tuberculosis infection., Am J Respir Crit Care Med. , 2011 , 184 ,732-737

Zhang T, Li SY, Converse PJ,... , Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infection., Antimicrob Agents Chemother , 2011 , 55 ,56-61

Zhang T, Bishai WR, Grosset JH,... , Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains., Antimicrob Agents Chemother. , 2010 , 54 , 7 ,2806-2813

Zhang T, Zhang M, Rosenthal IM,... , Short-course therapy with daily rifapentine in a murine model of latent tuberculosis infection., Am J Respir Crit Care Med. , 2009 , 180 ,1151-1157

Zhang T, Wang L,Xu G,Chen Y,Zhang Y,Li Y*. , Disruption of ste23 gene affects composition profile and bioactivity of exopolysaccharide produced by Streptomyces sp. 139., Lett App Microbiol. , 2006 , 42 , 2 ,132-137

Zhang T, Wang L,Xu G,Chen Y,Zhang Y,Li Y*. , Disruption of the ste22 Gene Encoding a Glycosyltransferase and Its Function in Biosynthesis of Ebosin in Streptomyces sp. 139., Curr Microbiol , 2006 , 52 , 1 ,55-59

专利

专利名称 专利类别 专利号 授权日期 发明人
一种硫链丝菌素-庆大霉素抗性基因体系及还有其的抗性表达盒和重组质粒 发明专利 2016101801161450 2016-10 张天宇, 马格文如.朱丽俄斯,刘燕,王邦兴,曹元元,黄少波,玛卡芬.盖乐, 张洋,郭锦涛,柴然吉比.筹多拉瑞,刘洋
吲哚-2-酮-3-螺噻嗪酮或噻唑酮化合物及其应用 发明专利 申请号:2016106571617 2016-05 涂正超,朱强,张天宇,黄金波,徐晓冰,万军庭,黎敏科,李登科,周亚丽,刘志永,王邦兴,米琦.托特雷拉
一种可投送自主发光元件的分枝杆菌噬菌体及其应用 发明专利 201610127984.9 2016-05 张天宇,刘志永
一种海洋链霉菌及其环肽化合物在制备抗结核分分枝杆菌药物中的应用 发明专利 申请号: 201610255638.9 2016-05 鞠建华,马俊英,张天宇,刘志永
一种检测结核分支杆菌耐药性的DNA标记物及其应用 发明专利 申请号:201610564946.X 2016-05 张天宇,摩西·M·恩扎瑞,王邦兴,刘志永,韩轶,刘燕,刘洋
吲哚[3,2-c]喹啉类化合物或其药学上可接受的盐及其制备方法和应用(2013) 发明专利 ZL201310385431.X 2016-04 朱强,张天宇,刘兰英,鲁明辉,毛婷婷,黄金波
一种用于高效构建无抗性标记重组分枝杆菌的抗性表达盒(2013) 发明专利 ZL 201310386264.0 2015-09 张天宇,杨峰,邹文英
构建无选择标记的自主发光脓肿分枝杆菌的方法及建立相应体外高通量筛药模型 发明专利 申请号:201510104936.3 2015-05 张天宇,曹元元,伍甜,谭守勇,谭耀驹,蔡杏珊,刘春平
吡唑并[1,5-a]吡啶类化合物及其应用 发明专利 201410562805.5 2014-05 陆小云,汤健,丁克,张天宇,涂正超,伍甜,万军庭,曹元元
N-4-三氟甲基苯基水杨酰胺衍生物的制备方法和应用(2014) 发明专利 申请号:201410073672.5 2014-05 丁克,陆小云,张天宇,汤健,鲁明辉,李宇鹏,张章,梁镇兴,钱政江
整合质粒pOPHI及无抗性筛选标记的自主发光分枝杆菌(2012) 发明专利 ZL 201210183007.2 2013-10 张天宇,杨峰,刘佳

最新待转化成果

完成时间 待转化成果
2018-10 抗耐药结核分枝杆菌1.1类新药TB47及新型结核病诊断产品的研发