链脲佐菌素STZ

糖尿病造模方法技术材料《STZ造模小知识》

编号：B2001
中文品名：链脲佐菌素 、链脲霉素 
英文名称：Streptozocin 
≥75% α-anomer basis, ≥98% (HPLC), powder  CAS号 18883-66-4 
经验分子式（希尔表示法） C8H15N3O7 
分子量 265.22 

• 技术说明书

基本信息

性质

产品描述

链脲佐菌素或链脲佐菌素是从不产色链霉菌中获得的。链脲佐菌素是一种葡糖胺-亚硝基脲，是一种仅通过GLUT2葡萄糖转运蛋白进入细胞的DNA烷化剂。一种致糖尿病剂，对于产生胰岛素的胰岛β-细胞具有特别的毒性。它对GLUT2阳性神经内分泌肿瘤细胞具有毒性。

链脲菌素或链脲佐菌素用于诱导糖尿病动物模型，该化合物可用于胰腺β细胞癌的治疗，本公司所提供产品，仅供动物使用。

可提供 100mg/500mg/1g三个包装规格产品。

一种在胰岛中可作为一氧化氮供体的含N-亚硝基化合物；诱导胰岛素分泌细胞的死亡，产生糖尿病动物模型。可诱导染色体断裂的有效DNA甲基化剂。 对表达GLUT2葡萄糖转运蛋白的神经内分泌肿瘤细胞系具有细胞毒性。

技术规格说明书

FT-IR Condensed Phase

FT-IR Raman

FT-NMR

S0130 - Product Information Sheet (57 KB)

安全信息

Danger

危害声明 个人防护装备 

Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

危害码 (欧洲) T

风险声明 (欧洲) 45   安全声明 (欧洲)  53-45  RIDADR UN 3077 9 / PGIII  WGK德国 3  RTECS LZ5775000

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?

If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

How should I store Product S0130, Streptozocin, upon receipt?

Streptozocin should be stored at -20 degrees C with desiccation. The desiccant is to prevent moisture uptake which can shorten shelf-life.

How do I store solutions of Product S0130, Streptozocin?

Aqueous solutions rapidly undergo mutarotation to an equilibrium mixture of alpha- and beta-anomers. Maximum solution stability is at pH 4, with stability decreasing rapidly at higher or lower pH. Freshly prepared solutions are clear and have a light straw color. On standing, they take on a yellow to brown color and effervesce, indicating decomposition. Solutions should be prepared just before use, since the product is unstable.

What is the half-life of Product S0130, Streptozocin?

Streptozocin has a reported half life of 15 to 30 minutes.

How can I make a solution of Product S0130, Streptozocin?

This product dissolves in water at 50 mg/mL to give a light yellow solution, from clear to slightly hazy. We recommend using a 20 mM citrate buffer at pH 4.5 for best solution stability.

CanProduct S0130, Streptozocin, be used to induce diabetes? What concentration should be used?

We do not test Streptozocin, Product No. S0130 for biological activity.We recommend screening lots for biological activity.An intravenous injection of streptozocin into rats at a dose of 65 mg/kg body weight to induce diabetes has been reported by Burcelin R. et al. in Biochem. J., 291, 109-113 (1993).

How do I get lot-specific information or a Certificate of Analysis?

The lot specific COA document can be found by entering the lot number above under the "Documents" section.

How do I find price and availability?

There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.

What is the Department of Transportation shipping information for this product?

Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

My question is not addressed here, how can I contact Technical Service for assistance?

Ask a Scientist here.

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Did you use this product in your Paper? If so click here.

The Streptozotocin-Induced Diabetic Nude Mouse Model: Differences between Animals from Different Sources Melanie L Graham Comparative Medicine 61(4), 356-360, (2011)

Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans Chinedum Journal of diabetes and metabolic disorders 12, 60-60, (2013)

Housekeeping proteins: How useful are they in skeletal muscle diabetes studies and muscle hypertrophy models? Marco Analytical Biochemistry 504, 38-40, (2016)

Acute stimulation of brain mu opioid receptors inhibits glucosestimulated insulin secretion via sympathetic innervation Eva Tuduri Neuropharmacology 110, 322-332, (2016)

Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice Sung-Hsun Yu PLoS ONE , -, (2016)

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Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner.

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The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), undefined (2015-4-4)

Diabetes is a common comorbidity in stroke patients and a strong predictor of poor functional outcome. To provide a more mechanistic understanding of this clinically relevant problem, we focused on how diabetes affects blood-brain barrier (BBB) funct...

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.

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Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease.

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Neuropharmacology, 72, undefined (2013-4-23)

Type 2 diabetes (T2D) is one of the major risk factors associated with Alzheimer's disease (AD). Recent studies have found similarities in molecular mechanisms that underlie the respective degenerative developments in the two diseases. Pharmacologica...

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes.

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Periostin induces pancreatic regeneration.

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We found that the secreted protein periostin (Postn) is highly induced after partial pancreatectomy in regenerating areas containing mesenchymal stroma and tubular complexes. Importantly, after partial pancreatectomy, Postn-deficient mice exhibit imp..

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技术支持:
北京博爱港生物技术有限公司在糖尿病造模上积累了较多的经验和数据，更多技术服务可联系技术支持。www.boaigang.com

糖尿病造模方法技术材料《STZ造模小知识》