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货号HY-12353A
品牌MedChemExpress(MCE)
品牌类型自有品牌(制造商)
货期现货
CAS号1629869-44-8
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品牌 | MedChemExpress(MCE) | |
基础属性 | 生产企业 | MCE中国 |
cas号 | 1629869-44-8 | |
规格 | 25 mg | |
储存条件 | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 month | |
纯度 | 99.45% | |
密度 |
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 1629869-44-8
MCE 国际站:Pimodivir
产品活性:Pimodivir (VX-787) 是一种可口服的甲型流感病毒聚合酶抑制剂,通过抑制PB2亚基起作用。
研究领域:Anti-infection
作用靶点:Influenza Virus
In Vitro: Pimodivir rescues macrophages from virus-mediated death at non-cytotoxic concentrations 24 hpi. The EC50 value for Pimodivir are 8 and 12 nM for A(H1N1) and A(H3N2) strains, respectively, whereas the CC50 values are >1 μM, giving selectivity indexes (SI) > 125 and > 83 for A(H1N1) and A(H3N2) strains, respectively. Pimodivir significantly attenuates the transcription of viral M1 RNA in macrophages, which are infected with A(H1N1) or A(H3N2) strains for 8 h. Pimodivir inhibits the transcription of viral but not cellular genes. Pimodivir allows some activation of IAV-mediated expression of several cellular genes, which are involved in tryptophan and nucleotide metabolism. Pimodivir possesses excellent anti-IAV but not immuno/metabolo-modulating effect. Pimodivir (VX-787) is very potent against influenza A strains, including pandemic 2009 H1N1 and avian H5N1. Pimodivir (VX-787) shows potent activity against all influenza A virus strains tested, with an EC50 range of 0.13 to 3.2 nM. Pimodivir-selected PB2 variant viruses maintain susceptibility to neuraminidase inhibitors in vitro.
In Vivo: Pimodivir (2, 6, and 20 mg/kg/day, p.o.) and GS 4071 (20 mg/kg/day) completely prevent death in the H1N1pdm virus infection in mice. Pimodivir (20 mg/kg/day) is more effective than GS 4071 (20 mg/kg/day) in improving body weight and reducing the severity of lung infection. Moreover, Pimodivir (VX-787) shows 100% survival in a +48 h delay to treatment mouse influenza model at 10, 3 and 1 mpk (BID × 10 days) whereas the SOC, GS 4071, provide no survival benefit in this model at 10 mpk. Pimodivir (VX-787; 1, 3, or 10 mg/kg, bid) provided complete survival, with a dose-dependent reduction in BW loss of the mice.
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Clinical Compound Library | Antiviral Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Orally Active Compound Library | Acetylcysteine | U0126-EtOH | Tunicamycin | Vadimezan | Favipiravir | Curcumin | Camptothecin | Aprotinin | Oseltamivir acid | Geldanamycin | Emricasan | Rifampicin | Baicalein | AG-1478 | Mycophenolic acid | AEBSF hydrochloride | Nitazoxanide | α-Vitamin E | GSK 650394 | Umifenovir hydrochloride | Spermine | Isoliquiritigenin | Oxymatrine | Pentagalloylglucose | Catechin | 6-Diazo-5-oxo-L-nor-Leucine | Naringenin | Harringtonine | Zanamivir
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